RapamycinFungusV1, Main, Exploration, bibRecord, 001786

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Identifieur interne : 001786 ( Main/Exploration ); précédent : 001785; suivant : 001787

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Auteurs : Masahiro Uritani [Japon] ; Hidetoshi Hidaka ; Yukari Hotta ; Masaru Ueno ; Takashi Ushimaru ; Takashi Toda

Source :

Genes to cells : devoted to molecular & cellular mechanisms [ 1356-9597 ] ; 2006.

RBID : pubmed:17121544

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Apoptosis (MeSH), Cell Proliferation (MeSH), GTP Phosphohydrolases (metabolism), Genes, Fungal (MeSH), Molecular Sequence Data (MeSH), Mutation (MeSH), Nitrogen (metabolism), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Protein Structure, Tertiary (MeSH), Schizosaccharomyces (genetics), Schizosaccharomyces (metabolism), Schizosaccharomyces pombe Proteins (genetics), Schizosaccharomyces pombe Proteins (metabolism), Sequence Homology, Amino Acid (MeSH), Temperature (MeSH).
MESH :
- chemical , genetics : Phosphatidylinositol 3-Kinases, Schizosaccharomyces pombe Proteins.
- chemical , metabolism : GTP Phosphohydrolases, Nitrogen, Phosphatidylinositol 3-Kinases, Schizosaccharomyces pombe Proteins.
- genetics : Schizosaccharomyces.
- metabolism : Schizosaccharomyces.
- Amino Acid Sequence, Apoptosis, Cell Proliferation, Genes, Fungal, Molecular Sequence Data, Mutation, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Temperature.

Abstract

The target of rapamycin (Tor) plays a pivotal role in cell growth and metabolism. Yeast contains two related proteins, Tor1 and Tor2. In fission yeast, Tor1 is dispensable for normal growth but is involved in amino acid uptake and cell survival under various stress conditions. In contrast, Tor2 is essential for cell proliferation; however, its physiological function remains unknown. Here we characterize the roles of fission yeast Tor2 by creating temperature sensitive (tor2(ts)) mutants. Remarkably, we have found that tor2(ts) mimics nitrogen starvation responses, because the mutant displays a number of phenotypes that are normally induced only on nitrogen deprivation. These include G1 cell-cycle arrest with a small cell size, induction of autophagy and commitment to sexual differentiation. By contrast, tor1Deltator2(ts) double mutant cells show distinct phenotypes, as the cells cease division with normal cell size in the absence of G1 arrest. Tor2 physically interacts with the conserved Rhb1/GTPase. Intriguingly, over-expression of rhb1(+) or deletion of Rhb1-GAP-encoding tsc2(+) is capable of rescuing stress-sensitive phenotypes of the tor1 mutant, implying that Tor1 and Tor2 also share functions in cell survival under adverse environment. We propose that Tor1 and Tor2 are involved in both corroborative and independent roles in nutrient sensing and stress response pathways.

DOI: 10.1111/j.1365-2443.2006.01025.x
PubMed: 17121544

Affiliations:

Japon

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Le document en format XML

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<author><name sortKey="Uritani, Masahiro" sort="Uritani, Masahiro" uniqKey="Uritani M" first="Masahiro" last="Uritani">Masahiro Uritani</name>
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<author><name sortKey="Hotta, Yukari" sort="Hotta, Yukari" uniqKey="Hotta Y" first="Yukari" last="Hotta">Yukari Hotta</name>
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<author><name sortKey="Ueno, Masaru" sort="Ueno, Masaru" uniqKey="Ueno M" first="Masaru" last="Ueno">Masaru Ueno</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Apoptosis (MeSH)</term>
<term>Cell Proliferation (MeSH)</term>
<term>GTP Phosphohydrolases (metabolism)</term>
<term>Genes, Fungal (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Nitrogen (metabolism)</term>
<term>Phosphatidylinositol 3-Kinases (genetics)</term>
<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
<term>Protein Structure, Tertiary (MeSH)</term>
<term>Schizosaccharomyces (genetics)</term>
<term>Schizosaccharomyces (metabolism)</term>
<term>Schizosaccharomyces pombe Proteins (genetics)</term>
<term>Schizosaccharomyces pombe Proteins (metabolism)</term>
<term>Sequence Homology, Amino Acid (MeSH)</term>
<term>Temperature (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose (MeSH)</term>
<term>Azote (métabolisme)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Gènes fongiques (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Phosphatidylinositol 3-kinases (génétique)</term>
<term>Phosphatidylinositol 3-kinases (métabolisme)</term>
<term>Prolifération cellulaire (MeSH)</term>
<term>Protéines de Schizosaccharomyces pombe (génétique)</term>
<term>Protéines de Schizosaccharomyces pombe (métabolisme)</term>
<term>Schizosaccharomyces (génétique)</term>
<term>Schizosaccharomyces (métabolisme)</term>
<term>Similitude de séquences d'acides aminés (MeSH)</term>
<term>Structure tertiaire des protéines (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Température (MeSH)</term>
<term>dGTPases (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term>
<term>Schizosaccharomyces pombe Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>GTP Phosphohydrolases</term>
<term>Nitrogen</term>
<term>Phosphatidylinositol 3-Kinases</term>
<term>Schizosaccharomyces pombe Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Phosphatidylinositol 3-kinases</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Azote</term>
<term>Phosphatidylinositol 3-kinases</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
<term>dGTPases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Apoptosis</term>
<term>Cell Proliferation</term>
<term>Genes, Fungal</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Protein Structure, Tertiary</term>
<term>Sequence Homology, Amino Acid</term>
<term>Temperature</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term>
<term>Données de séquences moléculaires</term>
<term>Gènes fongiques</term>
<term>Mutation</term>
<term>Prolifération cellulaire</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Structure tertiaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Température</term>
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<front><div type="abstract" xml:lang="en">The target of rapamycin (Tor) plays a pivotal role in cell growth and metabolism. Yeast contains two related proteins, Tor1 and Tor2. In fission yeast, Tor1 is dispensable for normal growth but is involved in amino acid uptake and cell survival under various stress conditions. In contrast, Tor2 is essential for cell proliferation; however, its physiological function remains unknown. Here we characterize the roles of fission yeast Tor2 by creating temperature sensitive (tor2(ts)) mutants. Remarkably, we have found that tor2(ts) mimics nitrogen starvation responses, because the mutant displays a number of phenotypes that are normally induced only on nitrogen deprivation. These include G1 cell-cycle arrest with a small cell size, induction of autophagy and commitment to sexual differentiation. By contrast, tor1Deltator2(ts) double mutant cells show distinct phenotypes, as the cells cease division with normal cell size in the absence of G1 arrest. Tor2 physically interacts with the conserved Rhb1/GTPase. Intriguingly, over-expression of rhb1(+) or deletion of Rhb1-GAP-encoding tsc2(+) is capable of rescuing stress-sensitive phenotypes of the tor1 mutant, implying that Tor1 and Tor2 also share functions in cell survival under adverse environment. We propose that Tor1 and Tor2 are involved in both corroborative and independent roles in nutrient sensing and stress response pathways.</div>
</front>
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<Abstract><AbstractText>The target of rapamycin (Tor) plays a pivotal role in cell growth and metabolism. Yeast contains two related proteins, Tor1 and Tor2. In fission yeast, Tor1 is dispensable for normal growth but is involved in amino acid uptake and cell survival under various stress conditions. In contrast, Tor2 is essential for cell proliferation; however, its physiological function remains unknown. Here we characterize the roles of fission yeast Tor2 by creating temperature sensitive (tor2(ts)) mutants. Remarkably, we have found that tor2(ts) mimics nitrogen starvation responses, because the mutant displays a number of phenotypes that are normally induced only on nitrogen deprivation. These include G1 cell-cycle arrest with a small cell size, induction of autophagy and commitment to sexual differentiation. By contrast, tor1Deltator2(ts) double mutant cells show distinct phenotypes, as the cells cease division with normal cell size in the absence of G1 arrest. Tor2 physically interacts with the conserved Rhb1/GTPase. Intriguingly, over-expression of rhb1(+) or deletion of Rhb1-GAP-encoding tsc2(+) is capable of rescuing stress-sensitive phenotypes of the tor1 mutant, implying that Tor1 and Tor2 also share functions in cell survival under adverse environment. We propose that Tor1 and Tor2 are involved in both corroborative and independent roles in nutrient sensing and stress response pathways.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Source :

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English descriptors

Abstract

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